Pair Name	Gambogic Acid, Fluorouracil
Disease Info	[ICD-11: 2B72.Z]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	CASP3	hsa836
	Up-regulation	Cleavage	PAEP	hsa5047
	Down-regulation	Expression	PARP1	hsa142
In Vitro Model	BGC-823	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_3360
In Vivo Model	Forty mice were inoculated sub cutaneously with injections of 1×10⁶ BGC-823 cells/mouse.
Result	Our data showed that GA attenuated 5-FU-induced apoptosis by modulating metabolic enzymes of 5-FU and the antigastric cancer effect of two drugs combination was much stronger than that of GA or 5-FU alone.