Pair Name | Gambogic Acid, Fluorouracil | ||
Phytochemical Name | Gambogic Acid (PubChem CID: 9852185 ) | ||
Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Gambogic Acid, Fluorouracil | |||
Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
Biological Phenomena | Induction-->Apoptosis | |||
Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
Down-regulation | Expression | CASP3 | hsa836 | |
Up-regulation | Cleavage | PAEP | hsa5047 | |
Down-regulation | Expression | PARP1 | hsa142 | |
In Vitro Model | BGC-823 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_3360 |
In Vivo Model | Forty mice were inoculated sub cutaneously with injections of 1×10⁶ BGC-823 cells/mouse. | |||
Result | Our data showed that GA attenuated 5-FU-induced apoptosis by modulating metabolic enzymes of 5-FU and the antigastric cancer effect of two drugs combination was much stronger than that of GA or 5-FU alone. |
No. | Title | Href |
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1 | Synergistic effect of 5-fluorouracil with gambogic acid on BGC-823 human gastric carcinoma. Toxicology. 2009 Feb 4;256(1-2):135-40. doi: 10.1016/j.tox.2008.11.014. | Click |